"The Fighting O'Briens" as Phil Farrand, the Star Trek Nitpicker calls them, provide an uneasy age gap moment.
In "Rascals," the episode where several characters "de-age," one of those characters is Miles O'Brien's wife, Keiko. She de-ages to eleven. I honestly don't know if the episode could even run now.
But in fact, the subsequent relationship problem is handled quite well. Miles is uneasy. His wife--who can't see herself--is much more matter-of-fact. She doesn't get upset until her daughter doesn't recognize her.
The issue is quickly resolved--thank goodness--so Miles doesn't have to decide when exactly his wife will become his wife again. He is a good, honorable man--so does he wait until she is exactly 18? Or bid goodbye to the marriage? Accept a platonic relationship? And if she lives with him as she grows up, won't he start to treat her like a daughter, even unintentionally?
The whole "Claudia as vampire--is maturity a matter of the mind or of biology?" problem luckily doesn't have to be resolved. But as always with Star Trek's "What if?" scenarios, the problem is interesting.